Probably to become with out Lucas Biglia, Lazio are preparing for any challenging test at Bayer Leverkusen.
Lazio coach Stefano Pioli was left hopeful over Lucas Biglia's injury as he looked ahead to Wednesday's Champions League clash against Bayer Leverkusen.
Biglia, a reported transfer target for Manchester United, came off inside the 52nd minute of Lazio's 2-1 Serie A win over Bologna on Saturday.
The club confirmed Biglia, who opened the scoring in the victory, had suffered a calf injury that would call for additional tests to figure out its severity.
Pioli was hopeful as Lazio prepare to head to Germany for the play-off getting won the initial leg 1-0.
"Our subsequent game is hugely essential as it'll tell us which European competitors we are going to take component in," he told Sky Sport Italia.
"The team is competitive. Sadly, we had a handful of also lots of injuries and hope Lucas Biglia doesn't have something critical."
Leverkusen may also take winning form in to the second leg right after overcoming Hannover 1-0 within the Bundesliga on Saturday.
Meanwhile, Monaco welcome Valencia to the Stade Louis II with the La Liga outfit holding a 3-1 advantage.
Both failed to win league matches on Saturday as Monaco have been held at Toulouse and Valencia drew at Rayo Vallecano.
Manchester United are well-placed to attain the group stages as they head to Club Brugge also top 3-1.
Marouane Fellaini's late aim at Old Trafford has given them a two-goal buffer, but Louis van Gaal's guys are struggling for ambitions - having scored just twice in 3 league games this season.
There remains higher uncertainty about all the other ties.
Leigh Griffiths' brace helped Celtic beat Malmo, however the Swedish side host the second leg right after the 3-2 loss in Scotland.
Shakhtar Donetsk will fancy their chances of reaching the group stages, top Speedy Vienna 1-0 ahead with the second leg in Ukraine.
Basel take a look at Israel's Maccabi Tel Aviv right after a 2-2 draw in Switzerland, when Astana head to APOEL holding a 1-0 lead.
CSKA Moscow are trailing 2-1 ahead of hosting Sporting Lisbon and BATE take a 1-0 bring about Partizan Belgrade.
Croatian club Dinamo Zagreb hold the upper-hand in their tie against Skenderbeu Korce, obtaining won the initial leg 2-1 in Albania.

Manchester United and Real Madrid in the summer transfer war continues, Degea impasse this aside, the question on Ramos, the Red Devils want to continue to try.

"Aspen" revealed that Manchester United to Real Madrid made a latest offer: 45 million euros, the Red Devils do not want to give up the fight to Ramos. Although Real Madrid hold Ramos, but contract negotiations collapse, according to the players and the club has been, is currently in a stalemate, Manchester United believe that they have the opportunity to profit therefrom.

The latest offer for Manchester United, Real Madrid turned down very firmly, they bite from the outset told Manchester United's price: € 90 million, exactly twice as the Red Devils latest offer.

Manchester United immediately made new comments, they told Real Madrid: If you talk about Ramos, we do not talk to you about Degea. It appears that the Red Devils this latest offer, in addition to test, or a small resort on the negotiating strategy.

Real Madrid to keep Ramos's attitude is very firm, in Casillas second farewell meeting, Real Madrid fans directed at Florentino shouting "Ramos is not for sale!", While Real Madrid statement said Chairman : "There are some players that the club did not want to let them go, and they will not go."

Ramos and De Gea transfer in battle, Manchester United is the most negative aspect of the player's own wishes, although the Red Devils not bad money, give Ramos out of the five-year contract (annual salary of 11 million euros), but There are indications that the first will of Ramos and Real Madrid still raises renewal, Manchester United and Real Madrid may just continue the game he used to raise alarm chips, is compelling record. A noteworthy phenomenon is that, to date, only speculation Ramos Spanish media wants to go, but I have never been publicly vocal Ramos said, "want to go", which is obviously very clever means of operation. In contrast, Degea himself is bent to Real Madrid, which is the biggest difference between the two pens move.